| Product Name | RIP Rabbit mAb |
| Background | Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Function: Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B. PTM: Autophosphorylated on serine and threonine residues. PTM: Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Similarity: Contains 1 death domain. similarity: Contains 1 protein kinase domain. subunit: Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1. |
| Reactivity | Human |
| Source | Rabbit, IgG Kappa |
| Applications | WB; IHC; IF; IP; ELISA |
| Dilutions | WB: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:200-1:1000; IP: 1:50-1:200; ELISA: 1:5000-1:20000 |
| MW (kDa) | Calculated: 76; Observed: 76 |
| Purification | Protein A |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage and Stability | -20°C/1 year |
| UniProt Accession # | Q13546 |
| Protein Name | RIP |
| Gene Name | RIPK1 RIP RIP1 |
| Gene ID | 8737 |
