Product Name | HDAC4 Rabbit mAb |
Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] |
Reactivity | Human; Mouse; Rat |
Source | Rabbit, IgG Kappa |
Applications | WB; IHC; IF; IP; ELISA |
Dilutions | WB: 1:2000-1:10000; IHC: 1:50-1:200; IF: 1:200-1:1000; IP: 1:50-1:200; ELISA: 1:5000-1:20000 |
Purification | Protein A |
Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
Storage and Stability | -20°C/1 year |
MW (kDa) | Calculated: 119; Observed: 140 |
UniProt Accession # | P56524 |
Protein Name | HDAC4 |
Gene Name | HDAC4 |
Gene ID | 9759 |
Other Names | HDAC4; KIAA0288; Histone deacetylase 4; HD4 |