Chk1 Rabbit Monoclonal Antibody

Chk1 Rabbit Monoclonal Antibody

Clone ID: PT0606R

$230.00$600.00

Cat #: MR3415
Product NameChk1 Rabbit mAb
Background The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
ReactivityHuman; Mouse; Rat
SourceRabbit, IgG Kappa
ApplicationsWB; IF; IP; ELISA
DilutionsWB: 1:2000-1:10000; IF: 1:200-1:1000; IP: 1:50-1:200; ELISA: 1:5000-1:20000
PurificationProtein A
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage and Stability-20°C/1 year
MW (kDa)Calculated: 54; Observed: 54
UniProt Accession #O14757
Protein NameChk1
Gene NameCHEK1
Gene ID1111
Other NamesCHEK1; CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1