AIF-M1 Rabbit Monoclonal Antibody

AIF-M1 Rabbit Monoclonal Antibody

Clone ID: PT0650R

$230.00$600.00

Cat #: MR3459
Product NameAIF-M1 Rabbit mAb
Background This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome
ReactivityHuman; Mouse; Rat
SourceRabbit, IgG Kappa
ApplicationsWB; IHC; IF; IP; ELISA
DilutionsWB: 1:2000-1:10000; IHC: 1:200-1:1000; IF: 1:200-1:1000; IP: 1:50-1:200; ELISA: 1:5000-1:20000
PurificationProtein A
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage and Stability-20°C/1 year
MW (kDa)Calculated: 67; Observed: 67
UniProt Accession #O95831
Protein NameAIF-M1
Gene NameAIFM1
Gene ID9131
Other NamesAIFM1; AIF; PDCD8; Apoptosis-inducing factor 1; mitochondrial; Programmed cell death protein 8